Discovery of new 2-phenyl-1H-benzo[d]imidazole core-based potent α-glucosidase inhibitors: Synthesis, kinetic study, molecular docking, and in vivo anti-hyperglycemic evaluation
Yue Li, Jinhe Zhang, Jinhe Zhang, Hong-Xu Xie, Yong-Xi Ge, Kaiming Wang, Zhiling Song, Kongkai Zhu, Juan Zhang, Juan Zhang, Cheng‐Shi Jiang
Topics & Concepts
ChemistryAcarboseIn vivoDocking (animal)StereochemistryEnzymeImidazoleIC50CytotoxicityAllosteric regulationIn vitroPolar surface areaActive siteBiochemistryMoleculeOrganic chemistryBiotechnologyMedicineNursingBiologyNatural Antidiabetic Agents StudiesCarbohydrate Chemistry and SynthesisEnzyme Production and Characterization