SLC40A1+ macrophages contribute to the immunosuppressive tumor microenvironment in EGFR-mutated lung cancer
Xinyu Song, Zongjuan Li, Xuanhe Wang, Du He, Yijun Jia, Shen Chen, Anwen Xiong, Wei Li, Xuefei Li, Lei Cheng, Chao Zhao, Lei Wang, Guanghui Gao, Xiaoxia Chen, Chunyan Wu, Zhikai Zhao, Shengxiang Ren, Caicun Zhou, Fengying Wu
Abstract
SLC40A1 + macrophages promote Treg differentiation through the CCL18-CCR8 axis and participate in the formation of immunosuppressive microenvironment after EGFR-TKI resistance.
Topics & Concepts
Tumor microenvironmentLung cancerCancer researchMedicineTumor cellsOncologyLung Cancer Treatments and MutationsRNA modifications and cancerCancer Immunotherapy and Biomarkers