Synthesis of novel calcium channel blockers with ACE2 inhibition and dual antihypertensive/anti-inflammatory effects: A possible therapeutic tool for COVID-19
Shahenda Mahgoub, Mohamed-I Kotb El-Sayed, Mohamed F. El Shehry, Samir M. Awad, Yara E. Mansour, Samar S. Fatahala
Topics & Concepts
NifedipineChemistryPharmacologyCalcium channelCalcium channel blockerCalciumInhibitory postsynaptic potentialCoronavirus disease 2019 (COVID-19)InflammationAnti-inflammatoryChannel blockerVoltage-dependent calcium channelInternal medicineMedicineOrganic chemistryDiseaseInfectious disease (medical specialty)Computational Drug Discovery MethodsPharmacological Receptor Mechanisms and EffectsCancer, Stress, Anesthesia, and Immune Response