Establishment of succinic acid production in recombinant Kluyveromyces marxianus enhanced by AI-guided enzyme specificity engineering and redox-controlled fermentation optimization
Du-Wen Zeng, Yifan Zhu, Yuan-Hong Jiang, Ya-Hao Ding, Zhenzhi Wang, Kai Li, Sha Liao, Ya-Chao Fan, Lin Zhang, Yuguang Wang, Xin‐Qing Zhao
Topics & Concepts
Kluyveromyces marxianusSuccinic acidBiochemistryMetabolic engineeringFermentationEnzymeChemistryHeterologousSubstrate (aquarium)YeastBioreactorEscherichia coliProtein engineeringRecombinant DNAMalic enzymeDirected evolutionFumaraseHeterologous expressionInulinaseEnzyme assayMalic acidBiologyIndustrial microbiologySaccharomyces cerevisiaeSubstrate specificityMicrobial Metabolic Engineering and BioproductionEnzyme Catalysis and ImmobilizationBiofuel production and bioconversion