A nano-predator of pathological MDMX construct by clearable supramolecular gold(I)-thiol-peptide complexes achieves safe and potent anti-tumor activity
Siqi Yan, Jin Yan, Dan Liu, Xiang Li, Qianyan Kang, Weiming You, Jinghua Zhang, Lei Wang, Zhiqi Tian, Wuyuan Lu, Wenjia Liu, Wangxiao He
Abstract
Collectively, this work not only provided a clinically viable paradigm for the treatment of a wide variety of tumors by multiple administration types, but, more importantly, it bridged the chasm between peptides and PROTACs, and likely reinvigorated the development of peptide-derived proteolysis-targeting chimeras for a great variety of diseases.
Topics & Concepts
MDMXProteolysisChemistryPeptideColloidal goldUbiquitinCancer researchBiophysicsBiochemistryNanotechnologyMdm2NanoparticleBiologyMaterials scienceEnzymeApoptosisGeneProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways