Synthesis of 1,2,3-triazole-piperazin-benzo[ <i>b</i> ][1,4]thiazine 1,1-dioxides: antibacterial, hemolytic and <i>in silico</i> TLR4 protein inhibitory activities
N. Ramu, Thupurani Murali Krishna, Ravikumar Kapavarapu, Sirassu Narsimha
Abstract
pharmacokinetic profile was predicted for potent compounds 8d, 8e and 6i using SWISS/ADME, All compounds investigated in this study adhered to Lipinski's rule of five with slight deviation in molecular weight (8d and 8e).
Topics & Concepts
In silicoThiazineChemistryInhibitory postsynaptic potentialAntibacterial activityMinimum inhibitory concentrationTriazoleStereochemistryCombinatorial chemistryIn vitroBiochemistryMedicinal chemistryBacteriaBiologyOrganic chemistryGeneNeuroscienceGeneticsSynthesis and biological activityClick Chemistry and ApplicationsSynthesis and Characterization of Heterocyclic Compounds