Clickable amino acid tuned self-assembly of a nucleus-selective multi-component nanoplatform for synergistic cancer therapy
Lan Yang, Xiao He, Zhiying Zeng, Jiakun Tang, Dongmei Qi, Huijie Ma, Hui Chen, Xinghai Ning, Xuli Feng
Abstract
can promote the rapid self-assembly of Ce6 and DOX in aqueous solution, avoiding the introduction of organic solvents or tedious preparations. In addition, the introduction of the DIBO group can effectively expand the types of self-assembly material and enhance the self-assembly behaviour through a copper-free click reaction. Therefore, we present an effective nucleus-targeted combination drug delivery strategy, which has great potential in the treatment of many diseases.
Topics & Concepts
Photodynamic therapyNucleusDoxorubicinChemistryIn vivoCombinatorial chemistryCancer therapyNanotechnologyBiophysicsDrug deliveryLysineMaterials scienceCancerBiochemistryAmino acidChemotherapyOrganic chemistryBiologyNeuroscienceBiotechnologyGeneticsNanoplatforms for cancer theranosticsSupramolecular Self-Assembly in MaterialsLuminescence and Fluorescent Materials