MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration
Scarlett J. Barker, Ravikiran M. Raju, Noah Milman, Jun Wang, José Dávila-Velderrain, Fatima Gunter‐Rahman, Cameron Parro, P. Lorenzo Bozzelli, Fatema Abdurrob, Karim Abdelaal, David A. Bennett, Manolis Kellis, Li‐Huei Tsai
Abstract
in the PS19 mouse model of tauopathy and found that this was sufficient to improve cognitive flexibility and reduce hyperexcitability. Overall, our findings reveal a previously unappreciated role for MEF2 TFs in promoting CgR, highlighting their potential as biomarkers or therapeutic targets for neurodegeneration and healthy aging.
Topics & Concepts
NeurodegenerationNeuroscienceBiologyCognitive declineCognitionMef2PopulationDiseaseDementiaTranscription factorMedicineEnhancerGeneticsGenePathologyEnvironmental healthGenetics and Neurodevelopmental DisordersNeurogenesis and neuroplasticity mechanismsMitochondrial Function and Pathology