Age-Related Cognitive and Motor Decline in a Mouse Model of CDKL5 Deficiency Disorder is Associated with Increased Neuronal Senescence and Death
Laura Gennaccaro, Claudia Fuchs, Manuela Loi, Riccardo Pizzo, Sara Alvente, Chiara Berteotti, Leonardo Lupori, Giulia Sagona, Giuseppe Galvani, Antonia Gurgone, Alessandra Raspanti, Giorgio Medici, Marianna Tassinari, Stefania Trazzi, Elisa Ren, Roberto Rimondini, Tommaso Pizzorusso, Giovanna Zoccoli, Maurizio Giustetto, Elisabetta Ciani
Abstract
KO mice, which suggests that an absence of Cdkl5 accelerates neuronal senescence/death by triggering irreparable DNA damage. In summary, this work provides evidence that CDKL5 may play a fundamental role in neuronal survival during brain aging and suggests a possible worsening with age of the clinical picture in CDD patients.
Topics & Concepts
SenescenceNeuroscienceHippocampusCognitive declineCognitionNeurodevelopmental disorderMedicineDiseasePsychologyInternal medicineAutismPsychiatryDementiaGenetics and Neurodevelopmental DisordersCongenital heart defects researchEpigenetics and DNA Methylation