PROTACs bearing piperazine-containing linkers: what effect on their protonation state?
Jenny Desantis, Andrea Mammoli, Michela Eleuteri, Alice Coletti, Federico Croci, Antonio Macchiarulo, Laura Goracci
Abstract
The p K a values of a dataset of PROTACs and PROTAC precursors have been analyzed in order to show how a fine modulation of piperazine-containing linkers can impact their protonation state.
Topics & Concepts
ProtonationPiperazineBearing (navigation)ChemistryCombinatorial chemistryStereochemistryOrganic chemistryComputer scienceArtificial intelligenceIonProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis