Testis-enriched <i>Asb15</i> is not required for spermatogenesis and male fertility in mice.
Yibo Wu, Ranran Zhang, Cong Shen, Jin‐Fu Xu, Tiantian Wu, Xiaoyan Huang, Mingxi Liu, Hong Li, Dewu Xu, Bo Zheng
Abstract
BACKGROUND: is enriched in mouse testis, it may have a role in spermatogenesis. METHODS AND RESULTS: -dKO mice also showed normal fertility, except for an increase in giant cells in testicular tubules, suggesting a minor functional compensation between the two genes during spermatogenesis. CONCLUSIONS: was individually not required for spermatogenesis or for fertility in mice. However, further investigation might be needed to reach a firm conclusion. These findings can prevent redundant research by other scientists and provides new information for further studies on the genetics of fertility in humans.
Topics & Concepts
SpermatogenesisBiologyAndrologySpermFertilitySomatic cellMale infertilityReproductive technologyMale fertilityGeneGeneticsEndocrinologyInfertilityEmbryogenesisMedicinePopulationEnvironmental healthPregnancySperm and Testicular FunctionAnimal Genetics and ReproductionGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities