Plasma gelsolin modulates the production and fate of IL-1β-containing microparticles following high-pressure exposure and decompression
Veena M. Bhopale, Deepa Ruhela, Kaighley Brett, Nathan Z. Nugent, Noelle K. Fraser, Susan L. Levinson, Mark J. DiNubile, Stephen R. Thom
Abstract
Inflammatory microparticles released in response to high pressure and decompression express surface filamentous actin. Infusion of recombinant human plasma gelsolin lyses these particles in decompressed mice and ameliorates particle-associated vascular damage. Human neutrophils also respond to high pressure with an increase in surface filamentous actin and microparticle production, and these events are inhibited by plasma gelsolin. Gelsolin infusion may have benefit as prophylaxis or treatment for decompression sickness.
Topics & Concepts
GelsolinDecompressionChemistryActinCell biologyMedicineAndrologyImmunologySurgeryBiologyBiochemistryBlood properties and coagulationErythrocyte Function and PathophysiologyCellular Mechanics and Interactions