Emergence of <i>fexA</i> in Mediating Resistance to Florfenicols in Campylobacter
Biao Tang, Yizhi Tang, Ling Zhang, Xiao Liu, Jiang Chang, Xiaodong Xia, Hua Yang, Zhangqi Shen
Abstract
Florfenicol belongs to a class of phenicol antimicrobials widely used as feed additives and for the treatment of respiratory infections. In recent years, increasing resistance to florfenicol has been reported in Campylobacter spp., the leading foodborne enteric pathogens causing diarrheal diseases worldwide. Here, we reported the identification of fexA , a novel mobile florfenicol resistance gene in Campylobacter . Of the 100 Campylobacter jejuni strains isolated from poultry in Zhejiang, China, 9 were shown to be fexA positive, and their whole-genome sequences were further determined by integration of Illumina short-read and MinION long-read sequencing.