<i>Aspergillus fumigatus</i> Can Display Persistence to the Fungicidal Drug Voriconazole
Jennifer Scott, Clara Valero, Álvaro Mato-López, Ian J. Donaldson, Alejandra Roldán, Harry Chown, Norman van Rhijn, Rebeca Lobo-Vega, Sara Gago, Takanori Furukawa, Alma Morogovsky, Ronen Ben‐Ami, Paul Bowyer, Nir Osherov, Thierry Fontaine, Gustavo H. Goldman, Emilia Mellado, Michael Bromley, Jorge Amich
Abstract
The phenomena of antibacterial tolerance and persistence, where pathogenic microbes can survive for extended periods in the presence of cidal drug concentrations, have received significant attention in the last decade. Several mechanisms of action have been elucidated, and their relevance for treatment failure in bacterial infections demonstrated.
Topics & Concepts
VoriconazoleAspergillus fumigatusFungicidePersistence (discontinuity)DrugAspergillusBiologyMicrobiologyPharmacologyAntifungalBotanyEngineeringGeotechnical engineeringAntifungal resistance and susceptibilityFungal Infections and StudiesMicrobial Natural Products and Biosynthesis