Facile Access to AgOCF<sub>3</sub> and Its New Applications as a Reservoir for OCF<sub>2</sub> for the Direct Synthesis of N−CF<sub>3</sub>, Aryl or Alkyl Carbamoyl Fluorides
Abdurrahman Türksoy, Thomas Scattolin, Samir Bouayad‐Gervais, Franziska Schoenebeck
Abstract
Abstract The development of innovative fluorination strategies is greatly dependent also on the availability, safety and practicability of available fluorinating reagents. We herein show a straightforward and quantitative strategy for the preparation of valuable AgOCF 3 at room temperature and showcase its performance in trifluoromethoxylations or as reservoir for O=CF 2 . This enabled the direct, practical and safe synthesis of valuable N‐alkyl/aryl and N−CF 3 carbamoyl fluorides from secondary amines and isothiocyanides, respectively. Our mechanistic data indicate that AgOCF 3 does not liberate O=CF 2 until it is activated by a nucleophilic co‐reagent, reinforcing the stability of the salt under our new preparation strategy.