Berberine Depresses Inflammation and Adjusts Smooth Muscle to Ameliorate Ulcerative Colitis of Cats by Regulating Gut Microbiota
Xueying Li, Shuang Xu, Yanhe Zhang, Kan Li, Xuejiao Gao, Mengyao Guo
Abstract
Ulcerative colitis (UC) is common in clinics. Intestinal microbiota disorder is correlated with ulcerative colitis. Although there are many studies on ulcerative colitis in rats, there are few studies on colitis in cats. Therefore, this study explored the possibility of the use of BBR as a safe and efficient treatment for colitis in cats. The results demonstrated the therapeutic effects of BBR on UC based on the state of the intestinal flora. The study found BBR supplementation to be effective against dextran sulfate sodium (DSS)-induced colitis, smooth muscle damage, and gut microbiota dysbiosis.
Topics & Concepts
Ulcerative colitisGut floraDysbiosisColitisInflammationBiologyImmunologyMicrobiologyMedicineInternal medicineDiseaseBerberine and alkaloids researchGut microbiota and healthGastrointestinal motility and disorders