SIRT6 activates PPARα to improve doxorubicin-induced myocardial cell aging and damage
Shulin Wang, Xuan Zhang, Yanhong Hou, Yuliang Zhang, Jiamin Chen, Shuhan Gao, Huiying Duan, Shaoju Gu, Shanshan Yu, Yi Cai
Topics & Concepts
SIRT6SenescenceOxidative stressGene silencingApoptosisDoxorubicinCD36Downregulation and upregulationSirtuinCancer researchBiologyCell biologyChemistryAcetylationBiochemistryGeneChemotherapyGeneticsSirtuins and Resveratrol in MedicineCalcium signaling and nucleotide metabolismPARP inhibition in cancer therapy