Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain
Chen Chen, Gaohong Fu, Quanqiang Guo, Song Xue, Shizhong Luo
Topics & Concepts
CarcinogenesisSuppressorMutationCancerFunction (biology)BiologyCancer researchMutantCancer cellCell biologyGeneMechanism (biology)CellChemistryGeneticsEpistemologyPhilosophyRNA Research and SplicingNuclear Structure and FunctionRNA modifications and cancer