Prediction of chronological and biological age from laboratory data
Luke Sagers, Luke Melas-Kyriazi, Chirag J. Patel, Arjun K. Manrai
Abstract
= 0.25). Variability was observed in which biomarkers carry predictive power across age groups, genders, and race/ethnicity groups, and novel candidate biomarkers of aging were identified for specific age ranges (e.g. Vitamin E, ages 18-44). We show that predictors for one age group may fail to generalize to other groups and investigate non-linearity in biomarkers near adulthood. As populations worldwide undergo major demographic changes, it is increasingly important to catalogue biomarker variation across age groups and discover new biomarkers to distinguish chronological and biological aging.
Topics & Concepts
BiomarkerCohortMedicinePopulationDemographyAge groupsBiological ageLimitingBiomarker discoveryGerontologyInternal medicineBiologyGeneticsProteomicsGeneEngineeringSociologyMechanical engineeringEnvironmental healthExplainable Artificial Intelligence (XAI)Health, Environment, Cognitive Aging