Potential inhibitors of coronavirus 3-chymotrypsin-like protease (3CL<sup>pro</sup>): an<i>in silico</i>screening of alkaloids and terpenoids from African medicinal plants
Gideon Ampoma Gyebi, Olalekan Bukunmi Ogunro, Adegbenro P. Adegunloye, Oludare M. Ogunyemi, Saheed O. Afolabi
Abstract
were identified from the predictive ADME/tox and Lipinski filter analysis. However, further experimental analyses are required for developing these possible leads into natural anti-COVID-19 therapeutic agents for combating the pandemic.Communicated by Ramaswamy H. Sarma.
Topics & Concepts
DruggabilityIn silicoDocking (animal)RitonavirLopinavirCoronavirusTerpenoidBiologyBiochemistryChemistryPharmacologyVirologyCoronavirus disease 2019 (COVID-19)MedicineVirusInfectious disease (medical specialty)DiseaseAntiretroviral therapyViral loadNursingGenePathologyDiverse Scientific Research StudiesComputational Drug Discovery MethodsSARS-CoV-2 and COVID-19 Research