Multi-specific niflumic acid platinum(<scp>iv</scp>) complexes displaying potent antitumor activities by improving immunity and suppressing angiogenesis besides causing DNA damage
Linming Li, Ming Zhang, Dianlong Jia, Zhifang Liu, Ning Zhang, Bin Sun, Zhengping Wang, Min Liu, Qingpeng Wang
Abstract
T infiltrating cells. Subsequently, the pathway ERK/HIF-1α/VEGFA associated with angiogenesis was suppressed by the reduced inflammation and elevated immune response, and the density of microvessels marked by CD34 was significantly reduced in tumors. Accordingly, the multi-specific NFA platinum(IV) complexes have great potential to be developed as novel anti-proliferative and anti-metastatic drugs.
Topics & Concepts
AngiogenesisChemistryCancer researchCisplatinApoptosisDNA damageIn vivoImmune systemInflammationPharmacologyCell biologyBiochemistryImmunologyBiologyDNAChemotherapyBiotechnologyGeneticsMetal complexes synthesis and propertiesCancer Mechanisms and TherapyDendrimers and Hyperbranched Polymers