Clinical response and changes in the fecal microbiota and metabolite levels after fecal microbiota transplantation in patients with inflammatory bowel disease and recurrent <i>Clostridioides difficile</i> infection.
Hayato Osaki, Yasutaka Jodai, Keishi Koyama, Takafumi Omori, Noriyuki Horiguchi, Toshiaki Kamano, Kohei Funasaka, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Naoki Ohmiya
Abstract
OBJECTIVES: infection (rCDI). METHODS: A filtered solution of Japanese donor feces was endoscopically administered. The efficacy of FMT was evaluated after 8 weeks using the Mayo score, Crohn's Disease Activity Index (CDAI), and the absence of diarrhea with stool toxin negativity in patients with active UC, CD, and rCDI, respectively. For fecal microbiota analysis, the 16S ribosomal RNA gene was sequenced, and fecal SCFA levels were measured. RESULTS: clusters IV and XIVa before FMT and higher abundances after FMT accompanied by elevated fecal propionate concentrations. CONCLUSIONS: FMT exhibited various efficacy against UC, CD, and rCDI by altering the gut microbiota and SCFA production.