Tumor-derived exosomes induce neutrophil infiltration and reprogramming to promote T-cell exhaustion in hepatocellular carcinoma
Wenchao Bi, Xue Li, Yu Jiang, Tongtong Gao, Huajun Zhao, Qiuju Han, Jian Zhang
Abstract
This study clarified the roles of HCC exosomes on neutrophil infiltration and reprogramming and identified a potential target miR-362-5p for HCC treatment.
Topics & Concepts
Hepatocellular carcinomaReprogrammingInfiltration (HVAC)MicrovesiclesCancer researchMedicineInflammationPathologyCellChemistryImmunologymicroRNAPhysicsThermodynamicsBiochemistryGeneExtracellular vesicles in diseasePhagocytosis and Immune RegulationImmune cells in cancer