G protein inhibitory α subunit 2 is a molecular oncotarget of human glioma
Yin Wang, Fang Liu, Jiang Wu, Meiqing Zhang, Jin-long Chai, Cong Cao
Abstract
studies revealed that Gαi2 shRNA-expressing AAV intratumoral injection hindered growth of subcutaneous glioma xenografts in nude mice. Moreover, Gαi2 KO inhibited intracranial glioma xenograft in nude mice. Gαi2 depletion, NFκB inhibition and apoptosis induction were observed in subcutaneous and intracranial glioma xenografts with Gαi2 depletion. Together, overexpressed Gαi2 is important for glioma cell growth possibly by promoting NFκB cascade activation.
Topics & Concepts
GliomaCancer researchApoptosisGene silencingSmall hairpin RNAEctopic expressionBiologyIn vivoTransfectionChemistryMolecular biologyCell cultureGene knockdownGeneBiochemistryGeneticsBiotechnologyCaveolin-1 and cellular processesGlioma Diagnosis and TreatmentPancreatic and Hepatic Oncology Research