Doxorubicin-loaded pH-responsive porphyrin-derived carbon dots as a promising biocompatible drug delivery system for effective chemotherapy of breast cancer
Abeer Ansary, Ahmed Osman, Mohamed E. El‐Khouly
Abstract
). Analysis by fluorescence microscopy and flow cytometry demonstrated that the enhanced cytotoxicity of the DOX@CDs complex compared to free DOX correlated with its greater cellular uptake and localization in cancerous cells. Notably, the nanocomposite exhibited reduced hemolytic activity, indicating enhanced biocompatibility. Our findings suggest that porphyrin-derived CDs hold promise as a safe and effective nanocarrier for targeted DOX delivery, offering a potential strategy to improve the therapeutic efficacy of breast cancer chemotherapy.
Topics & Concepts
DoxorubicinPorphyrinBiocompatible materialDrug deliveryDrugAnticancer drugChemistryChemotherapyBreast cancerCancerPharmacologyNanotechnologyMaterials scienceMedicineBiomedical engineeringOrganic chemistryInternal medicineCarbon and Quantum Dots ApplicationsGraphene and Nanomaterials ApplicationsNanocluster Synthesis and Applications