Iron-promoted free radical cascade difunctionalization of unsaturated benzamides with silanes
Yaxin Ge, Yunfei Tian, Jilai Wu, Qinqin Yan, Luping Zheng, Yingming Ren, Jincan Zhao, Zejiang Li
Abstract
Iron salt/peroxide promoted cascade difunctionalization of unsaturated benzamides with silanes has been reported. It provides a convenient, highly selective, and efficient protocol for the synthesis of various silylated dihydroisoquinolinones and 1,3-isoquinolinediones. In particular, the present methodology only gives cyclization products in good isolated yields under the typical conditions.
Topics & Concepts
SilanesChemistryCascadeCombinatorial chemistryPeroxideSalt (chemistry)Hydrogen peroxideOrganic chemistrySilaneChromatographyCatalytic C–H Functionalization MethodsAdvanced Synthetic Organic ChemistrySynthesis and Biological Activity