lncRNA STEAP3-AS1 Modulates Cell Cycle Progression via Affecting CDKN1C Expression through STEAP3 in Colon Cancer
Heya Na, Xiaomeng Li, Xinsheng Zhang, Yue Xu, Yuzhu Sun, Jingyi Cui, Zihao Chen, Xiaomeng Shi, Shuangyi Ren, Yunfei Zuo
Abstract
phase. In tumorigenicity assays, STEAP3-AS1 knockdown could strongly inhibit tumor growth. Mechanistic investigations demonstrated that STEAP3-AS1 downregulation could increase the expression of cyclin-dependent kinase inhibitor 1C (CDKN1C) by STEAP3 upregulation. Overall, we identify the underlying role of MT1M-related lncRNA STEAP3-AS1 in colon cancer progression, which provides a novel strategy for colon cancer therapy.
Topics & Concepts
CarcinogenesisCancer researchBiologyGene knockdownDownregulation and upregulationCancerColorectal cancerTumor progressionCell growthLong non-coding RNACell cycleCell cultureGeneticsGeneCancer-related molecular mechanisms researchRNA Research and SplicingCircular RNAs in diseases