Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion of<i>Lactobacillus plantarum</i>WCFS1 to gut epithelial cells
Chunli Kong, Renate Akkerman, Cynthia E. Klostermann, Martin Beukema, Marjolein M. P. Oerlemans, Henk A. Schols, Paul de Vos
Abstract
WCFS1 to Caco-2 cells, while 3-FL had no such effect. Our findings illustrate that fermentation of hMOs is very structure-dependent and different from the commonly applied GOS/inulin, which might lead to differential potencies to stimulate adhesion of commensal cells to gut epithelium and consequent microbial colonization. This knowledge might contribute to the design of tailored infant formulas containing specific hMO molecules to meet the need of infants during the transition from breastfeeding to formula.
Topics & Concepts
InulinFermentationLactic acidLactobacillus plantarumPrebioticBifidobacteriumMicrobiologyFood scienceBacteriaLactobacillusGut floraChemistryButyric acidBacteroidesBiologyBiochemistryGeneticsInfant Nutrition and HealthProbiotics and Fermented FoodsDigestive system and related health