Quantifying and Modeling the Acquisition and Retention of Lumpy Skin Disease Virus by Hematophagus Insects Reveals Clinically but Not Subclinically Affected Cattle Are Promoters of Viral Transmission and Key Targets for Control of Disease Outbreaks
Beatriz Sanz‐Bernardo, Ismar R. Haga, Najith Wijesiriwardana, S Basu, Will Larner, Adriana V. Díaz, Zoë Langlands, Eric Denison, Joanne Stoner, Mia White, C. J. Sanders, Philippa C. Hawes, Anthony J. Wilson, John Atkinson, Carrie Batten, Luke Alphey, Karin E. Darpel, Simon Gubbins, Philippa M. Beard
Abstract
Lumpy skin disease virus (LSDV) causes a severe systemic disease characterized by cutaneous nodules in cattle. LSDV is a rapidly emerging pathogen, having spread since 2012 into Europe and Russia and across Asia. The vector-borne nature of LSDV transmission is believed to have promoted this rapid geographic spread of the virus; however, a lack of quantitative evidence about LSDV transmission has hampered effective control of the disease during the current epidemic. Our research shows subclinical cattle play little part in virus transmission relative to clinical cattle and reveals a low probability of virus acquisition by insects at the preclinical stage. We have also calculated the reproductive number of different insect species, therefore identifying efficient transmitters of LSDV. This information is of utmost importance, as it will help to define epidemiological control measures during LSDV epidemics and of particular consequence in resource-poor regions where LSD vaccination may be less than adequate.