Spontaneous local membrane curvature induced by transmembrane proteins
Christoph Kluge, Matthias Pöhnl, Rainer A. Böckmann
Abstract
). Analyses of protein-lipid interactions within the bicelle revealed that the potassium channel shapes the surrounding membrane via structural determinants. Differences in shape of the protein-lipid interface of the voltage-gating domains between the extracellular and cytosolic membrane leaflets induce membrane stress and thereby promote a protein-proximal membrane curvature. In contrast, the water pore AQP0 displayed a high structural stability and an only faint effect on the surrounding membrane environment that is connected to its wedge-like shape.
Topics & Concepts
CurvatureMembrane curvatureTransmembrane proteinBiophysicsMembraneMembrane proteinChemistryLipid bilayerElasticity of cell membranesMolecular dynamicsTransmembrane domainIntegral membrane proteinCrystallographyBiochemistryBiologyGeometryReceptorMathematicsComputational chemistryLipid Membrane Structure and BehaviorNanopore and Nanochannel Transport StudiesForce Microscopy Techniques and Applications