What a difference a methylene makes: replacing Glu with Asp or Aad in the Lys-urea-Glu pharmacophore of PSMA-targeting radioligands to reduce kidney and salivary gland uptake
Hsiou‐Ting Kuo, Kuo‐Shyan Lin, Zhengxing Zhang, Chengcheng Zhang, Helen Merkens, Ruiyan Tan, Áron Roxin, Carlos Uribe, François Bénard
Abstract
The aim of this study was to investigate the effect of replacing Glu in the Lys-urea-Glu PSMA-targeting pharmacophore of [ 68 Ga]Ga-HTK03041 with a close analog on the uptake of kidneys, salivary glands and PSMA-expressing tumor xenografts.
Topics & Concepts
BiodistributionLNCaPChemistryRadioligandKidneyCancer researchMolecular biologyNuclear medicineMedicineBiochemistryReceptorEndocrinologyIn vitroInternal medicineCancerBiologyProstate cancerRadiopharmaceutical Chemistry and ApplicationsProstate Cancer Treatment and ResearchNeuroblastoma Research and Treatments