WHO Critical Priority Escherichia coli as One Health Challenge for a Post-Pandemic Scenario: Genomic Surveillance and Analysis of Current Trends in Brazil
Bruna Fuga, Fábio P. Sellera, Louise Cerdeira, Fernanda Esposito, Brenda Cardoso, Herrison Fontana, Quézia Moura, Adriana Cardenas-Arias, Elder Sano, Rosineide M. Ribas, Albalúcia C. Carvalho, Maria Cristina Bronharo Tognim, Márcia Maria Camargo de Morais, Ana Judith Pires Garcia Quaresma, Ângela Patrícia Santana, Joice Neves Reis, Marcelo Pilonetto, Eliana Carolina Vespero, Raquel Regina Bonelli, Aloysio de Mello Figueiredo Cerqueira, Thaís Cristine Marques Sincero, Nilton Lincopán
Abstract
A One Health approach for antimicrobial resistance must integrate whole-genome sequencing surveillance data of critical priority pathogens from human, animal and environmental sources to track hot spots and routes of transmission and developing effective prevention and control strategies. As part of the Grand Challenges Explorations: New Approaches to Characterize the Global Burden of Antimicrobial Resistance Program, we present genomic data of WHO critical priority carbapenemase-resistant, ESBL-producing, and/or colistin-resistant Escherichia coli strains isolated from humans and nonhuman sources in Brazil, a country with continental proportions and high levels of antimicrobial resistance. The present study provided evidence of epidemiological and clinical interest, highlighting that the convergence of wide virulome and resistome has contributed to the persistence and rapid spread of international high-risk clones of E. coli at the human-animal-environmental interface, which must be considered a One Health threat that requires coordinated actions to reduce its incidence in humans and nonhuman hosts.