Visible-Light-Induced Regioselective Dicarbonylation of Indolizines with Oxoaldehydes via Direct C–H Functionalization
Lili Teng, Xiang Liu, Pengfeng Guo, Yue Yu, Hua Cao
Abstract
A metal-free system for regioselective dehydrogenative cross-couplings between indolizines and oxoaldehydes catalyzed by visible light under mild conditions has been described. As an atom economical and eco-friendly protocol, the reaction proceeds in good yields using inexpensive, readily available visible-light sources and the environmentally friendly oxidant oxygen. Various valuable 1,2-dicarbonyl derivatives attached to an indolizine core were easily accessed by the direct dicarbonylation of the sp2 C–H bond.
Topics & Concepts
RegioselectivityChemistryIndolizineSurface modificationCombinatorial chemistryEnvironmentally friendlyCarbazoleVisible spectrumPhotoredox catalysisCatalysisPhotochemistryOrganic chemistryPhotocatalysisOptoelectronicsPhysicsEcologyPhysical chemistryBiologySynthesis and Reactivity of HeterocyclesCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms