SNP characteristics and validation success in genome wide association studies
Olga Y. Gorlova, Xiangjun Xiao, Spiridon Tsavachidis, Christopher I. Amos, Ivan P. Gorlov
Topics & Concepts
Genome-wide association studySingle-nucleotide polymorphismBiologyGenetic associationSNPFalse positive paradoxLogistic regressionComputational biologyGeneticsHuman geneticsFalse discovery rateLinkage disequilibriumCross-validationMinor allele frequencyMultivariate statisticsHuman genomeTag SNP1000 Genomes ProjectMultiple comparisons problemAllele frequencyBioinformaticsRegressionGenetic modelGenomeFalse positive rateGenetic Associations and EpidemiologyGenomics and Rare DiseasesBRCA gene mutations in cancer