Indole Propionic Acid Regulates Gut Immunity: Mechanisms of Metabolite-Driven Immunomodulation and Barrier Integrity
Tao Ren, Dehui Li, Feng Sun, Lijia Pan, Ao Wang, Xinze Li, Yuwen Bao, Meiyu Zhang, Fei Zheng, Hao Yue
Abstract
, the mechanism of action on intestinal immunity, and the promise of its application in the treatment of related diseases. The physiological and biological effects of IPA were investigated to explore its potential application in future drug discovery. Obviously, IPA plays an important role in intestinal immunity and is effective in the treatment of related diseases. IPA helps regulate intestinal immune cell function, inhibiting inflammatory response and enhancing intestinal barrier function through its effects on the aryl hydrocarbon receptor, the pregnane X receptor, and other related signaling pathways. The development of IPA as a target drug for the treatment of intestinal diseases is promising. Although IPA research is still in the experimental animal model stage, there is growing interest in the many therapeutic applications of IPA and increasing opportunities to further modify IPA for future clinical applications.