A transdermal drug delivery system based on dissolving microneedles for boron neutron capture therapy of melanoma
Jiaxin Li, Xueyi Wang, Zhaoshuo Wang, Yu Zhao, Ziyang Zhang, Lanya Li, Dandan Ding, Junshu Guo, Jinchao Zhang, Huifang Liu, Zhenhua Li
Abstract
B accumulation and tumor-to-normal tissue (T/N) ratio. Herein, a dissolving microneedle-based transdermal drug delivery system was specifically designed for BNCT in a mouse model of melanoma. By incorporating fructose-BPA (F-BPA) into PVA microneedle tips, this system successfully delivered sufficient F-BPA into the melanoma site after the application of only two patches. Notably, the T/N ratio achieved through the treatment combining PVA/F-BPA MNs with BNCT (PVA/F-BPA MNs-BNCT) surpassed 93.16, signifying a great improvement. Furthermore, this treatment approach effectively inhibited tumor growth and significantly enhanced the survival rate of the mice. In brief, our study introduces a novel, simple, and efficient administration strategy for BNCT, opening new possibilities for the design of nanomedicine for BNCT.