HicA Toxin-Based Counterselection Marker for Allelic Exchange Mutations in Fusobacterium nucleatum
G C Bibek, Peng Zhou, Chenggang Wu
Abstract
Fusobacterium nucleatum is an indole-producing human oral anaerobe associated with periodontal diseases, preterm birth, and several cancers. Little is known about the mechanisms of fusobacterial pathogenesis and associated factors, mainly due to the lack of robust genetic tools for this organism.
Topics & Concepts
Fusobacterium nucleatumBiologyGeneticsPlasmidGeneOperonMutagenesisFrameshift mutationMicrobiologyMutationBacteriaEscherichia coliPorphyromonas gingivalisStreptococcal Infections and TreatmentsOral microbiology and periodontitis researchOtolaryngology and Infectious Diseases