Photodegradation of carbonic anhydrase by iridium complexes for induction of immunogenic cell death under hypoxia
Yu‐Yi Ling, Ya‐Jie Kong, Hao Liang, Zhengyin Pan, Zong‐Wan Mao, Cai‐Ping Tan
Abstract
Ir3 is reported to photodegrade CAIX under hypoxia, which improve the cancer immune microenvironment, and induce immunogenic pyroptosis through lipid peroxidation under hypoxia.
Topics & Concepts
Hypoxia (environmental)ChemistryLipid peroxidationImmune systemIridiumPyroptosisProgrammed cell deathCancer researchCell biologyApoptosisBiochemistryOxygenBiologyEnzymeImmunologyCatalysisOrganic chemistryAdenosine and Purinergic SignalingNanoplatforms for cancer theranosticsEnzyme function and inhibition