Native mass spectrometry and gas-phase fragmentation provide rapid and in-depth topological characterization of a PROTAC ternary complex
Jong Hee Song, Nicole D. Wagner, Jing Yan, Jing Li, Richard Y.‐C. Huang, Aaron Balog, John A. Newitt, Guodong Chen, Michael L. Gross
Topics & Concepts
Ternary complexUbiquitin ligaseChemistryDissociation (chemistry)Mass spectrometryTernary operationProtein subunitProteolysisCollision-induced dissociationFragmentation (computing)DNA ligaseBiophysicsTandem mass spectrometryUbiquitinBiochemistryChromatographyEnzymeBiologyPhysical chemistryComputer scienceGeneEcologyProgramming languageProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis