Cp*Rh(III)-Catalyzed Regioselective C(sp<sup>3</sup>)–H Electrophilic Trifluoromethylthiolation of 8-Methylquinolines
Sumit, Devesh Chandra, Ankita Thakur, Ankit Kumar Dhiman, Upendra Sharma
Abstract
Rh(III)-catalyzed regioselective trifluoromethylthiolation of the unactivated C(sp3)–H bond of 8-methylquinolines with bench-stable electrophilic trifluoromethylthiolating reagent via C(sp3)–H activation is explored. Various substituted 8-methylquinolines provided the products in good yields with high regioselectivity. Current reaction conditions are also applicable for the late-stage functionalization of natural molecule santonin and caffeine-substituted 8-methylquinoline.
Topics & Concepts
RegioselectivityChemistryElectrophileReagentCatalysisMedicinal chemistryElectrophilic additionOrganic chemistryFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques