Neutrophil-Associated Responses to Vibrio cholerae Infection in a Natural Host Model
Dustin Farr, Dhrubajyoti Nag, Walter Chazin, Simone Harrison, Ryan Thummel, Xixia Luo, Saumya Raychaudhuri, Jeffrey H. Withey
Abstract
'-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine (TPEN), but growth was recovered by the addition of the transition metals zinc and manganese. The expression of downstream calprotectin targets was also significantly increased in the zebrafish. These findings illuminate the role of host calprotectin in combating V. cholerae infection. Inhibition of V. cholerae growth through metal limitation may provide new approaches in the development of anti-V. cholerae therapeutics. This study also establishes a major role for calprotectin in combating infectious diseases in zebrafish.
Topics & Concepts
Vibrio choleraeBiologyHost (biology)MicrobiologyCholeraVibrionaceaeVirologyImmunologyBacteriaEcologyGeneticsVibrio bacteria research studiesImmune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative Mechanisms