Shatianyu (<i>Citrus grandis</i> L. Osbeck) whole fruit alleviated loperamide-induced constipation <i>via</i> enhancing gut microbiota-mediated intestinal serotonin secretion and mucosal barrier homeostasis
Mei Deng, Jiamin Ye, Ruifen Zhang, Shuai Zhang, Lihong Dong, Dongxiao Su, Mingwei Zhang, Fei Huang
Abstract
The effects of Citrus grandis Shatianyu whole fruit powder enriched in flavonoids and dietary fiber on loperamide-induced constipation after a 4-week administration in the diet, together with possible microbiota-mediated mechanisms were explored.
Topics & Concepts
LoperamideGut floraConstipationSecretionSerotoninLactobacillusDiarrheaBiologyMicrobiologyFood scienceInternal medicineMedicineImmunologyFermentationReceptorGastrointestinal motility and disordersGut microbiota and healthDermatology and Skin Diseases