Apple polyphenol extract ameliorates sugary-diet-induced depression-like behaviors in male C57BL/6 mice by inhibiting the inflammation of the gut–brain axis
Yisha Xie, Zhengli Wu, Qingfan Qian, Hao Yang, Jieyu Ma, Wenxue Luan, Siyuan Shang, Xinli Li
Abstract
C57BL/6 mice were fed with control diet, sugary-diet, or sugary-diet with APE gavage for 8 weeks. After behavioral testing, the samples of serum, hippocampus, colon, and colonic contents were collected for further determination.
Topics & Concepts
InflammationPolyphenolDepression (economics)C57BL/6BiologyGut–brain axisMedicineTraditional medicineEndocrinologyInternal medicineGut floraImmunologyBiochemistryAntioxidantEconomicsMacroeconomicsTryptophan and brain disordersDiet and metabolism studiesGut microbiota and health