Litcius/Paper detail

CRISPR: History and perspectives to the future

Zuzana Kozovská, S. Rajcaniova, P. Munteanu, S. Dzacovska, Lucia Demková

2021Biomedicine & Pharmacotherapy49 citationsDOIOpen Access PDF

Abstract

This review summarizes the information about the history and future of the CRISPR/Cas9 method. Genome editing can be perceived as a group of technologies that allow scientists to change the DNA of an organism. These technologies involve the deletion, insertion, or modification of the genome at a specific site in a DNA sequence. Gene therapy in humans has a perspective to be used to eliminate the gene responsible for a particular genetic disorder. The review focuses on the key elements of this promising method and the possibility of its application in the treatment of cancer and genetic diseases.

Topics & Concepts

CRISPRGenome editingOrganismComputational biologyBiologyGenomeCas9GeneGeneticsDNACRISPR and Genetic EngineeringInnovation and Socioeconomic DevelopmentPluripotent Stem Cells Research