Enhanced anti-tumor response elicited by a novel oncolytic HSV-1 engineered with an anti-PD-1 antibody
Chao Tian, Jiajia Liu, Hua Zhou, Jingfeng Li, Chunyang Sun, Wei Zhu, Yuxin Yin, Xiaopeng Li, Xiaopeng Li
Topics & Concepts
Oncolytic virusHerpes simplex virusTumor microenvironmentCancer researchImmune systemMonoclonal antibodyImmunotherapyBiologyTumor necrosis factor alphaCytokineAntibodyImmune checkpointIn vivoGenetic enhancementVirologyImmunologyVirusGeneBiotechnologyBiochemistryVirus-based gene therapy researchCAR-T cell therapy researchImmunotherapy and Immune Responses