Genome-Wide Analysis of Experimentally Evolved Candida auris Reveals Multiple Novel Mechanisms of Multidrug Resistance
Hans Carolus, Siebe Pierson, José F. Muñoz, Ana Subotić, Rita B. Cruz, Christina A. Cuomo, Patrick Van Dijck
Abstract
Candida auris is a recently discovered human fungal pathogen and has shown an alarming potential for developing multi- and pan-resistance toward all classes of antifungals most commonly used in the clinic. Currently, C. auris has been globally recognized as a nosocomial pathogen of high concern due to this evolutionary potential.
Topics & Concepts
Candida aurisMultiple drug resistanceGenomeBiologyGeneticsComputational biologyDrug resistanceMicrobiologyAntifungalGeneAntifungal resistance and susceptibilityFungal Infections and StudiesPneumocystis jirovecii pneumonia detection and treatment