Evolution of Multidrug Resistance in Plasmodium falciparum: a Longitudinal Study of Genetic Resistance Markers in the Greater Mekong Subregion
Mallika Imwong, Kanokon Suwannasin, Suttipat Srisutham, Ranitha Vongpromek, Cholrawee Promnarate, Aungkana Saejeng, Aung Pyae Phyo, Stephane Proux, Tiengkham Pongvongsa, Nguon Chea, Olivo Miotto, Rupam Tripura, Chau Nguyen Hoang, Lek Dysoley, Nghia Ho Dang Trung, Thomas J. Peto, James J. Callery, Rob W. van der Pluijm, Chanaki Amaratunga, Mavuto Mukaka, Lorenz von Seidlein, Mayfong Mayxay, Nguyen Thanh Thuy-Nhien, Paul N. Newton, Nicholas P. J. Day, Elizabeth A. Ashley, Francois H. Nosten, Frank M. Smithuis, Mehul Dhorda, Nicholas J. White, Arjen M. Dondorp
Abstract
in the same parasites was extremely rare (4/6,722 [0.06%]) and was dispersed over time. The mechanisms conferring mefloquine and piperaquine resistance may be counterbalancing. This supports the development of ASMQ plus piperaquine as a triple artemisinin combination therapy.