<scp>Cephalotane‐Type</scp> Norditerpenoids from <i>Cephalotaxus fortunei</i> var. <i>alpina</i>
Zhan‐Peng Ge, Bin Zhou, Flávia M. Zimbres, María B. Cassera, Jin‐Xin Zhao, Jian‐Min Yue
Abstract
Comprehensive Summary A chemical investigation of the 95% EtOH extract of the seeds of Cephalotaxus fortunei var. alpina led to the isolation of nine new cephalotane‐type norditerpenoids, ceforalides A—I (1—9), and two known analogues (10 and 11). Compounds 1—8 belong to a rare class of A‐ring‐contracted cephalotane‐type norditerpenoids, of which compound 8 incorporates a unique tetrasubstituted 2,5‐cyclohexadienone A‐ring. Compound 9 is a rare 13,14‐ seco ‐17‐ nor ‐cephalotane‐type diterpenoid. Their structures were determined based on NMR, HRESIMS, ECD, and X‐ray diffraction analysis. Biological tests revealed compounds 10 and 11 displayed moderate antimalarial activity.