Tetrahedral framework nucleic acids facilitate neurorestoration of facial nerves by activating the NGF/PI3K/AKT pathway
Yangxue Yao, Yuting Wen, Yanjing Li, Jianwei Zhu, Taoran Tian, Qi Zhang, Dexuan Xiao, Yang Gao, Yunfeng Lin, Wei Wei, Xiaoxiao Cai
Abstract
experiments also proved that tFNAs enhanced the expressions of axon and myelin marker proteins, impelled histological recovery, promoted the efficient restoration of nerve conduction and muscle movement. Additionally, tFNAs possessed excellent biocompatibility and superior endocytosis ability. Thus, there is good potential for tFNAs to be applied in the therapy of facial nerve injury or even peripheral nerve injury.
Topics & Concepts
Nucleic acidPI3K/AKT/mTOR pathwayFacial nerveProtein kinase BChemistryPeripheral nerveNerve growth factorNerve injuryMedicineAnatomySignal transductionBiochemistrySurgeryReceptorFacial Nerve Paralysis Treatment and ResearchNerve injury and regenerationHead and Neck Surgical Oncology