Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylation
Jie Hu, Qingzhu Gao, Yang Yang, Jie Xia, Wanjun Zhang, Yao Chen, Zhi Zhou, Lei Chang, Yuan Hu, Hui Zhou, Li Liang, Xiaosong Li, Quanxin Long, Kai Wang, Ailong Huang, Ni Tang
Abstract
. The findings reveal a link between HBP, O-GlcNAc modification, and innate antiviral immunity by targeting SAMHD1.
Topics & Concepts
ImmunoprecipitationSAMHD1In vivoHepatitis B virusBiologyIn vitroCell biologyViral replicationDownregulation and upregulationHippo signaling pathwayBiochemistryChemistryKinaseRNAVirusVirologyReverse transcriptaseGeneBiotechnologyGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and SynthesisBiochemical and Molecular Research